Phenotypes for Ern1 Speer6-ps1 MGI:4949418 MGI Mouse

increased hepatocyte apoptosis ( J:171230 )

• 5-times in response to Bortezomib treatment

increased liver triglyceride level ( J:171230 )

• following tamoxifen treatment

• following partial hepatectomy

• in response to Bortezomib treatment

abnormal hepatocyte morphology ( J:171230 )

• liver cells exhibit less rough endoplasmic reticulum content compared with control liver cells

hepatic steatosis ( J:171230 )

• mice exhibit a slight increase in hepatic lipid content compared with control mice

• mice subjected to liver stress (partial hepatectomy or treatment with tamoxifen or Bortezomib) exhibit increased accumulation of lipids in the liver compared with control mice

• however, phospholipid synthesis is normal

abnormal lipid level ( J:171230 )

• mice exhibit a slight increase in hepatic lipid content compared with control mice

• mice subjected to liver stress (partial hepatectomy or treatment with tamoxifen or Bortezomib) exhibit increased accumulation of lipids in the liver compared with control mice

• however, phospholipid levels in the liver are normal

decreased circulating cholesterol level ( J:171230 )

• following tamoxifen-treatment