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Phenotypes Associated with This Genotype
Genotype
MGI:4949205
Allelic
Composition
Foxo3mommeR1/Foxo3mommeR1
Tg(HBA1-GFP)1Ew/Tg(HBA1-GFP)1Ew
Genetic
Background
FVB/NJ-Foxo3mommeR1 Tg(HBA1-Gfp)1Ew
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo3mommeR1 mutation (2 available); any Foxo3 mutation (31 available)
Tg(HBA1-GFP)1Ew mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• at P3 some primordial follicles show an increase in the size of primary oocytes
• oocytes are less likely to have a polar body on ovulation

reproductive system
• oocytes are less likely to have a polar body on ovulation
• at 18 weeks of age
• at P30 compared to heterozygous controls
• in some ovaries a disproportionate increase in oocyte size relative to the follicular cells is seen at P30
• increase in the number of follicles at P30
• marked decrease in the number of primary follicles at P60
• increase in the number of secondary follicles at P30
• at 18 weeks of age ovarian follicles are absent in 3 of 4 mice and the remaining mouse has a few degenerating primordial follicles
• at P3 some primordial follicles show an increase in the size of primary oocytes
• at P14 most of the remaining primordial follicles contain an enlarged primary oocyte surrounded by spindle-shaped/squamous follicular cells
• marked decrease in the number of primordial follicles at P60
• at 18 weeks of age 1 of 4 mice has a few degenerating primordial follicles
• at P30 compared to heterozygous controls
• at 1 year of age occasional females have grossly enlarged ovaries
• found in grossly enlarged ovaries at 1 year of age
• Background Sensitivity: teratomas are seen in about 1 in 6 mice of aged up to 8 months in mice on an FVB/NJ background but not in mice on an inbred C57BL/6J background
• apparent asynchronous development of the oocyte and follicle
• females lose fertility by about 8 weeks of age
• however, males display normal fertility
• apparent asynchronous development of the oocyte and follicle
• at P3 some primordial follicles show an increase in the size of primary oocytes
• oocytes from superovulated females are less likely to have a polar body on the day of ovulation
• increased proportion of superovulated oocytes that are arrested at metaphase of meiosis I
• oocytes cultured overnight are more likely to fragment than those from superovulated heterozygous females

neoplasm
• found in grossly enlarged ovaries at 1 year of age
• Background Sensitivity: teratomas are seen in about 1 in 6 mice of aged up to 8 months in mice on an FVB/NJ background but not in mice on an inbred C57BL/6J background

growth/size/body
• at P30 compared to heterozygous controls
• at 1 year of age occasional females have grossly enlarged ovaries

mortality/aging
• females lose fertility by about 8 weeks of age
• however, males display normal fertility

endocrine/exocrine glands
• at 18 weeks of age
• at P30 compared to heterozygous controls
• in some ovaries a disproportionate increase in oocyte size relative to the follicular cells is seen at P30
• increase in the number of follicles at P30
• marked decrease in the number of primary follicles at P60
• increase in the number of secondary follicles at P30
• at 18 weeks of age ovarian follicles are absent in 3 of 4 mice and the remaining mouse has a few degenerating primordial follicles
• at P3 some primordial follicles show an increase in the size of primary oocytes
• at P14 most of the remaining primordial follicles contain an enlarged primary oocyte surrounded by spindle-shaped/squamous follicular cells
• marked decrease in the number of primordial follicles at P60
• at 18 weeks of age 1 of 4 mice has a few degenerating primordial follicles
• at P30 compared to heterozygous controls
• at 1 year of age occasional females have grossly enlarged ovaries
• found in grossly enlarged ovaries at 1 year of age
• Background Sensitivity: teratomas are seen in about 1 in 6 mice of aged up to 8 months in mice on an FVB/NJ background but not in mice on an inbred C57BL/6J background
• apparent asynchronous development of the oocyte and follicle

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
dermoid cyst of ovary DOID:5117 OMIM:166950
J:170710


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory