Phenotypes Associated with This Genotype

Genotype
MGI:4948839

• Allelic Composition: Keap1^tm1.1Sbis/Keap1^tm1.1Sbis; Tg(Scgb1a1-cre)1Grau/0
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

abnormal lung epithelium morphology ( J:170960 )

• mice exposed to cigarette smoke exhibit reduced respiratory epithelium oxidative stress and inflammation compared with similarly-treated wild-type cells

abnormal club cell morphology ( J:170960 )

• Clara cells exposed to hydrogen peroxide exhibit lower levels of reactive oxygen species compared with similarly-treated wild-type cells

homeostasis/metabolism

decreased susceptibility to injury ( J:170960 )

• mice exposed to cigarette smoke exhibit reduced respiratory epithelium oxidative stress and inflammation compared with similarly-treated wild-type cells