Mouse Genome Informatics
hm
    Ank1M1Wlst/Ank1M1Wlst
involves: 129S1/SvImJ * C3H/HeJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• many jaundice mice die within 2 weeks of birth
• the mean lifespan of mice that survive to adulthood is 28 weeks

hematopoietic system
• CFU-C progenitors are increased in the spleen and liver of adult mice compared to in wild-type mice
• total CFU-C, including and most severely affecting CFU-macrophage and CFU-granulocyte-macrophage progenitors, are reduced in the bone marrow of adult mice compared with wild-type mice
• adult mice exhibit increased amorphous red blood cells, red cell fragments, and nucleated red blood cells compared with wild-type mice
• in adult mice
• in adult mice
• adult mice exhibit a more than 10-fold increase in mature erythroblasts in the peripheral blood, doubling in the bone marrow, and a 25-fold increase in the spleen compared with wild-type mice
• CFU-E are increased 4-fold in the bone marrow and 125-fold in the spleen of adult mice
• in adult mice
• in adult mice
• severe in adult mice
• mice exhibit myelodysplasia with increased CFU-progenitors in the adult spleen and liver compared with wild-type mice
• profound in adult bone marrow, spleen, and liver
• in adult mice

growth/size
• mice that survive to weaning are runted compared with wild-type mice
• in adult mice

liver/biliary system
• in adult mice
• in some neonates

cardiovascular system
• in adult mice

integument
• at E17.5

immune system
• mice exhibit myelodysplasia with increased CFU-progenitors in the adult spleen and liver compared with wild-type mice
• in adult mice

Mouse Models of Human Disease
OMIM IDRef(s)
Spherocytosis, Type 1; SPH1 182900 J:170562