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Phenotypes Associated with This Genotype
Genotype
MGI:4948066
Allelic
Composition
Ank1M1Wlst/Ank1M1Wlst
Genetic
Background
involves: 129S1/SvImJ * C3H/HeJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ank1M1Wlst mutation (0 available); any Ank1 mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• many jaundice mice die within 2 weeks of birth
• the mean lifespan of mice that survive to adulthood is 28 weeks

hematopoietic system
• CFU-C progenitors are increased in the spleen and liver of adult mice compared to in wild-type mice
• total CFU-C, including and most severely affecting CFU-macrophage and CFU-granulocyte-macrophage progenitors, are reduced in the bone marrow of adult mice compared with wild-type mice
• mice exhibit myelodysplasia with increased CFU-progenitors in the adult spleen and liver compared with wild-type mice
• profound in adult bone marrow, spleen, and liver
• severe in adult mice
• adult mice exhibit a more than 10-fold increase in mature erythroblasts in the peripheral blood, doubling in the bone marrow, and a 25-fold increase in the spleen compared with wild-type mice
• CFU-E are increased 4-fold in the bone marrow and 125-fold in the spleen of adult mice
• in adult mice
• adult mice exhibit increased amorphous red blood cells, red cell fragments, and nucleated red blood cells compared with wild-type mice
• in adult mice
• in adult mice
• in adult mice
• in adult mice

growth/size/body
• mice that survive to weaning are runted compared with wild-type mice
• in adult mice

liver/biliary system
• in adult mice
• in some neonates

cardiovascular system
• in adult mice

integument
• at E17.5

immune system
• mice exhibit myelodysplasia with increased CFU-progenitors in the adult spleen and liver compared with wild-type mice
• in adult mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Spherocytosis, Type 1; SPH1 182900 J:170562


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory