Mouse Genome Informatics
hm
    Npr2cn-3J/Npr2cn-3J
MRL/MpJ-Npr2cn-3J/GrsrJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Disproportionate dwarf phenotype in Npr2cn-3J/Npr2cn-3J mice

growth/size/body
• homozygotes have a shorter body length, short noses, short limbs, short tails, and squared bellies

limbs/digits/tail

craniofacial

reproductive system
• female homozygotes breed poorly and have small litter sizes
• male homozygotes are not able to breed, but this is not due to a sperm defect since sperm functions satisfactorily for in vitro fertilization

Mouse Models of Human Disease
OMIM IDRef(s)
Achondroplasia; ACH 100800 J:170669