Phenotypes Associated with This Genotype

Genotype
MGI:4947974

• Allelic Composition: Xirp2^tm1Itl/Xirp2^tm1Itl
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:170869 )

N • mice exhibit normal cardiac fibrosis and apoptosis, ejection fraction, and fractional shortening

increased myocardial fiber size ( J:170869 )

• ventricular myocytes exhibit a 1.6-fold increase in cross-sectional area compared to in wild-type mice

increased heart weight ( J:170869 )

• modest at 9 to 15 weeks

cardiac hypertrophy ( J:170869 )

homeostasis/metabolism

abnormal response/metabolism to endogenous compounds ( J:170869 )

• angiotensin II-treated mice exhibit a reduced cardiac hypertrophy, cardiac fibrosis, and cardiac apoptosis unlike similarly treated wild-type mice

muscle

increased myocardial fiber size ( J:170869 )

• ventricular myocytes exhibit a 1.6-fold increase in cross-sectional area compared to in wild-type mice

growth/size/body

increased heart weight ( J:170869 )

• modest at 9 to 15 weeks

cardiac hypertrophy ( J:170869 )