About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4946296
Allelic
Composition
Bbc3tm1Gpz/Bbc3tm1Gpz
Trp53tm1Brd/Trp53tm8Xu
Genetic
Background
involves: 129P2/OlaHsd * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bbc3tm1Gpz mutation (0 available); any Bbc3 mutation (15 available)
Trp53tm1Brd mutation (7 available); any Trp53 mutation (150 available)
Trp53tm8Xu mutation (0 available); any Trp53 mutation (150 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• the segmental progeria phenotypes observed in Trp53tm1Brd/Trp53tm8Xu mice are rescued
• mice survive longer than Trp53tm1Brd/Trp53tm8Xu mice

reproductive system
N
• testes atrophy observed in Trp53tm1Brd/Trp53tm8Xu mice is rescued
• depletion of adult stem cells in the testes observed in Trp53tm1Brd/Trp53tm8Xu mice is rescued

immune system
• not as severe as in Trp53tm1Brd/Trp53tm8Xu mice

nervous system
N
• depletion of adult stem cells in the brain observed in Trp53tm1Brd/Trp53tm8Xu mice is rescued

digestive/alimentary system
N
• apoptosis in the crypt of small intestine observed in Trp53tm1Brd/Trp53tm8Xu mice is rescued

hematopoietic system
N
• depletion of adult stem cells in the bone marrow observed in Trp53tm1Brd/Trp53tm8Xu mice is rescued
• not as severe as in Trp53tm1Brd/Trp53tm8Xu mice

endocrine/exocrine glands
• not as severe as in Trp53tm1Brd/Trp53tm8Xu mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/15/2019
MGI 6.14
The Jackson Laboratory