Phenotypes Associated with This Genotype

Genotype
MGI:4946296

• Allelic Composition: Bbc3^tm1Gpz/Bbc3^tm1Gpz; Trp53^tm1Brd/Trp53^tm8Xu
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:170216 )

N • the segmental progeria phenotypes observed in Trp53^tm1Brd/Trp53^tm8Xu mice are rescued

N • mice survive longer than Trp53^tm1Brd/Trp53^tm8Xu mice

reproductive system

reproductive system phenotype ( J:170216 )

N • testes atrophy observed in Trp53^tm1Brd/Trp53^tm8Xu mice is rescued

N • depletion of adult stem cells in the testes observed in Trp53^tm1Brd/Trp53^tm8Xu mice is rescued

immune system

decreased thymocyte number ( J:170216 )

• not as severe as in Trp53^tm1Brd/Trp53^tm8Xu mice

nervous system

nervous system phenotype ( J:170216 )

N • depletion of adult stem cells in the brain observed in Trp53^tm1Brd/Trp53^tm8Xu mice is rescued

digestive/alimentary system

digestive/alimentary phenotype ( J:170216 )

N • apoptosis in the crypt of small intestine observed in Trp53^tm1Brd/Trp53^tm8Xu mice is rescued

hematopoietic system

hematopoietic system phenotype ( J:170216 )

N • depletion of adult stem cells in the bone marrow observed in Trp53^tm1Brd/Trp53^tm8Xu mice is rescued

decreased thymocyte number ( J:170216 )

• not as severe as in Trp53^tm1Brd/Trp53^tm8Xu mice

endocrine/exocrine glands

decreased thymocyte number ( J:170216 )

• not as severe as in Trp53^tm1Brd/Trp53^tm8Xu mice