Phenotypes Associated with This Genotype

Genotype
MGI:4943719

• Allelic Composition: Cry1^tm1Jhjh/Cry1^tm1Jhjh; Cry2^tm1Jhjh/Cry2^tm1Jhjh
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal circadian behavior period ( J:54241 )

• following entrainment to a light:dark regime, mice abruptly adapt to a new situation by starting wheel running as soon as light is off and expanding their period of fragmented activity unlike wild-type mice

arrhythmic circadian behavior persistence ( J:54241 )

• under dark:dark conditions

• however, mice exhibit normal circadian rhythm under light:dark conditions

immune system

abnormal T cell activation ( J:159504 )

• mice exhibit an increase in activated T cells compared with wild-type mice

increased circulating interleukin-1 beta level ( J:159504 )

• following treatment with anti-CII antibodies

increased circulating interleukin-6 level ( J:159504 )

• following treatment with anti-CII antibodies

• however, treatment with anti-TNF-alpha antibodies reduces serum levels of IL6 induced by anti-CII antibodies

increased circulating tumor necrosis factor level ( J:159504 )

• following treatment with anti-CII antibodies

• however, treatment with anti-TNF-alpha antibodies reduces serum levels of TNF-alpha induced by anti-CII antibodies

increased tumor necrosis factor secretion ( J:159504 )

• in splenocyte

increased susceptibility to induced arthritis ( J:159504 )

• following treatment with anti-CII antibodies, mice exhibit increased arthritis score and serum levels of TNF-alpha, IL1beta, IL6, and MMP3 compared with wild-type mice

• however, treatment with anti-TNF-alpha antibodies reduces induced arthritis score and levels of TNF-alpha, IL6, and MMP3

skeleton

increased susceptibility to induced arthritis ( J:159504 )

• following treatment with anti-CII antibodies, mice exhibit increased arthritis score and serum levels of TNF-alpha, IL1beta, IL6, and MMP3 compared with wild-type mice

• however, treatment with anti-TNF-alpha antibodies reduces induced arthritis score and levels of TNF-alpha, IL6, and MMP3

homeostasis/metabolism

increased circulating interleukin-1 beta level ( J:159504 )

• following treatment with anti-CII antibodies

increased circulating interleukin-6 level ( J:159504 )

• following treatment with anti-CII antibodies

• however, treatment with anti-TNF-alpha antibodies reduces serum levels of IL6 induced by anti-CII antibodies

increased circulating tumor necrosis factor level ( J:159504 )

• following treatment with anti-CII antibodies

• however, treatment with anti-TNF-alpha antibodies reduces serum levels of TNF-alpha induced by anti-CII antibodies

hematopoietic system

abnormal T cell activation ( J:159504 )

• mice exhibit an increase in activated T cells compared with wild-type mice