Mouse Genome Informatics
ht
    Gt(ROSA)26Sortm37(H1/tetO-RNAi:Taz)Arte/Gt(ROSA)26Sor+
involves: 129S6/SvEvTac * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
cardiovascular system
• after 8 months, cardiac muscles from doxycycline-treated mice exhibit abnormal mitochondria compared with wild-type mice
• after 8 months, cardiac ventricles from doxycycline-treated mice exhibit poorly arrayed sarcomeres compared to in wild-type mice
• at 8 months, doxycycline-treated mice exhibit increased left ventricular diameter and volume both at end diastole and end systole and reduced diastolic thickness of left ventricular posterior wall and interventricular septum compared with wild-type mice
• at 8 months, doxycycline-treated mice exhibit a reduction of left ventricular mass (LV wall volume) compared with wild-type mice
• at 8 months in a doxycycline-treated mice
• at 8 months, doxycycline-treated mice exhibit reduced fractional shortening and ejection fraction compared with wild-type mice

cellular
• doxycycline-treated mice exhibit an increase in mitochondria in the heart and muscles compared to in wild-type mice
• doxycycline-treated mice exhibit an increase in mitochondria in the heart and muscles compared to in wild-type mice

growth/size
• in doxycycline-treated mice after 8 months

muscle
• after 8 months, cardiac muscles from doxycycline-treated mice exhibit abnormal mitochondria compared with wild-type mice
• after 8 months, cardiac ventricles from doxycycline-treated mice exhibit poorly arrayed sarcomeres compared to in wild-type mice
• at 8 months, doxycycline-treated mice exhibit reduced fractional shortening and ejection fraction compared with wild-type mice
• after 8 months, cardiac ventricles from doxycycline-treated mice exhibit poorly arrayed sarcomeres compared to in wild-type mice
• at 2 months, skeletal muscles from doxycycline-treated mice exhibit increased number of mitochondria with various inner membrane abnormalities compared to in wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Barth Syndrome; BTHS 302060 J:167527