Phenotypes Associated with This Genotype

Genotype
MGI:4943530

• Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1⁺
• Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased intestinal adenoma incidence ( J:169830 )

• adults receiving a single tamoxifen dose at P60 demonstrated numerous microadenomas in the small intestines when analyzed at P105

digestive/alimentary system

abnormal small intestinal crypt cell proliferation ( J:169830 )

• adults receiving a single tamoxifen dose at P60 and analyzed at P105 show an expansion of the proliferative compartment from crypts to more distal epithelium

abnormal small intestine morphology ( J:169830 )

• adults receiving a single tamoxifen dose at P60 and analyzed at P105 show a general tissue disorganization of the small intestine

increased intestinal adenoma incidence ( J:169830 )

• adults receiving a single tamoxifen dose at P60 demonstrated numerous microadenomas in the small intestines when analyzed at P105

cellular

abnormal small intestinal crypt cell proliferation ( J:169830 )

• adults receiving a single tamoxifen dose at P60 and analyzed at P105 show an expansion of the proliferative compartment from crypts to more distal epithelium