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Phenotypes Associated with This Genotype
Genotype
MGI:4943327
Allelic
Composition
Tg(Csf1r-Tnfsf15,-EGFP)#Targ/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• the number of Paneth cells per villi in the duodenum, jejunum, and ileum is increased compared with wild-type mice (J:169462)
• the number of Paneth cells per villi in the duodenum, jejunum, and ileum is increased compared with wild-type mice (J:169462)
• the number of goblet cells per villi in the duodenum, jejunum, and ileum is increased compared with wild-type mice (J:169462)
• however, aged mice exhibit normal numbers of goblet cells (J:169462)
• the number of goblet cells per villi in the duodenum, jejunum, and ileum is increased compared with wild-type mice (J:169462)
• however, aged mice exhibit normal numbers of goblet cells (J:169462)
• ileum exhibit increased lamina propria mononuclear cell numbers compared to in wild-type mice (J:169462)
• ileum exhibit increased lamina propria mononuclear cell numbers compared to in wild-type mice (J:169462)
• villi are blunted at 2 and 10 months (J:169462)
• villi are blunted at 2 and 10 months (J:169462)
• in the colonic mucosa and submucosa by 10 months (J:169462)
• in the colonic mucosa and submucosa by 10 months (J:169462)
• mild, detected by myeloperoxidase (MPO) activity (J:169462)
• however, MPO activity in the colon is normal (J:169462)
• mild, detected by myeloperoxidase (MPO) activity (J:169462)
• however, MPO activity in the colon is normal (J:169462)

skeleton
• 2 of 58 mice develop arthropathy unlike wild-type mice (J:169462)
• 2 of 58 mice develop arthropathy unlike wild-type mice (J:169462)
• mice develop swollen joints that cause difficulty moving compared with wild-type mice (J:169462)
• mice develop swollen joints that cause difficulty moving compared with wild-type mice (J:169462)

immune system
• mild, detected by myeloperoxidase (MPO) activity (J:169462)
• however, MPO activity in the colon is normal (J:169462)
• mild, detected by myeloperoxidase (MPO) activity (J:169462)
• however, MPO activity in the colon is normal (J:169462)
• at 10 months, mice exhibit a 2-fold increase in CD4+ IFN-gamma+ cells in mesenteric lymph nodes compared with wild-type mice (J:169462)
• IFN-gamma production in the mesenteric lymph node compared to in wild-type mice (J:169462)
• at 10 months, mice exhibit a 2-fold increase in CD4+ IFN-gamma+ cells in mesenteric lymph nodes compared with wild-type mice (J:169462)
• IFN-gamma production in the mesenteric lymph node compared to in wild-type mice (J:169462)

integument
• 1 of 58 mice develop erythematous ulcerated skin lesions compared with 1 of 155 wild-type mice (J:169462)
• 1 of 58 mice develop erythematous ulcerated skin lesions compared with 1 of 155 wild-type mice (J:169462)

cardiovascular system

endocrine/exocrine glands
• the number of Paneth cells per villi in the duodenum, jejunum, and ileum is increased compared with wild-type mice (J:169462)
• the number of Paneth cells per villi in the duodenum, jejunum, and ileum is increased compared with wild-type mice (J:169462)

Mouse Models of Human Disease
OMIM ID Ref(s)
Inflammatory Bowel Disease 16; IBD16 612259 J:169462


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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory