Mouse Genome Informatics
tg
    Tg(Lck-Tnfsf15,-EGFP)#Targ/0
involves: C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
digestive/alimentary system
• villi are blunted at 2 and 10 months
• the number of paneth cells per villi in the duodenum, jejunum, and ileum is increased compared with wild-type mice
• however, the number of Paneth cells in the duodenum in aged mice is normal
• the number of goblet cells per villi in the duodenum, jejunum, and ileum is increased compared with wild-type mice
• however, aged mice exhibit normal numbers of goblet cells
• ileum exhibit increased lamina propria mononuclear cell numbers compared to in wild-type mice
• in the colonic mucosa and submucosa by 10 months
• mild, detected by myeloperoxidase (MPO) activity
• however, MPO activity in the colon is normal

immune system
• mild, detected by myeloperoxidase (MPO) activity
• however, MPO activity in the colon is normal
• at 2 months, CD4+ CD44+ T cells are increased 2-fold in the spleen compared to in wild-type mice
• at 10 months, CD4+ CD44+ T cells are increased in the spleen and mesenteric lymph nodes compared to in wild-type mice
• at 10 months, CD8+ CD44+ T cells are increased in the spleen and mesenteric lymph nodes compared to in wild-type mice
• at 10 months, mice exhibit a 3-fold increase in CD4+ IFN-gamma+ cells in mesenteric lymph nodes compared with wild-type mice
• IFN-gamma production in the mesenteric lymph node and small intestine lamina propria mononuclear cells compared to in wild-type mice
• at 10 months, mice exhibit a 2-fold increase in CD4+ IL17+ cells in mesenteric lymph nodes compared with wild-type mice

skeleton
• 2 of 51 mice develop arthropathy unlike wild-type mice
• 3 of 4 mice develop monoarticular arthropathy and the remaining mouse exhibited polyarticular arthropathy
• mice develop swollen joints that cause difficulty moving compared with wild-type mice

integument
• 2 of 51 mice develop erythematous ulcerated skin lesions compared with 1 of 155 wild-type mice

cardiovascular system

endocrine/exocrine glands
• the number of paneth cells per villi in the duodenum, jejunum, and ileum is increased compared with wild-type mice
• however, the number of Paneth cells in the duodenum in aged mice is normal

hematopoietic system
• at 2 months, CD4+ CD44+ T cells are increased 2-fold in the spleen compared to in wild-type mice
• at 10 months, CD4+ CD44+ T cells are increased in the spleen and mesenteric lymph nodes compared to in wild-type mice
• at 10 months, CD8+ CD44+ T cells are increased in the spleen and mesenteric lymph nodes compared to in wild-type mice

homeostasis/metabolism
• in the colonic mucosa and submucosa by 10 months

Mouse Models of Human Disease
OMIM IDRef(s)
Inflammatory Bowel Disease 16; IBD16 612259 J:169462