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Phenotypes Associated with This Genotype
Genotype
MGI:4943238
Allelic
Composition
Grhl2m1Nisw/Grhl2m1Nisw
Genetic
Background
129S1.B6-Grhl2m1Nisw
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl2m1Nisw mutation (1 available); any Grhl2 mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most mice die at E9.5

reproductive system
• female mice yield smaller than expected litters compared with wild-type mice

cardiovascular system
• anemic heart at E18.5
• at E18.5, ventricles contain larger spaces than in wild-type mice

embryo
• at E10.5, mice exhibit open, wavy neural folds unlike in wild-type mice
• however, mice exhibit normal patterning, proliferation, and differentiation in the neural tube

growth/size/body
• with upper jaw and upper part of the face failing to close
• however, the lower jaw is normal
• primary thoracoabdominoschisis in all mice at E12.5 or later

nervous system
• at E10.5, mice exhibit open, wavy neural folds unlike in wild-type mice
• however, mice exhibit normal patterning, proliferation, and differentiation in the neural tube
• in the hind-, mid-, and forebrain

respiratory system
• small and collapsed at E18.5

craniofacial
• with upper jaw and upper part of the face failing to close
• however, the lower jaw is normal


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory