Mouse Genome Informatics
cn
    Tg(Cma1-cre)ARoer/0
Tg(Kit*D814V)1Roer/0

involves: C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
digestive/alimentary system
• all mice develop intestinal inflammation similar to that in mice carrying Tg(Kit*D814V)1Roer and Tg(Mx1-cre)1Cgn

hematopoietic system
• develop mastocytosis similar to that in mice carrying Tg(Kit*D814V)1Roer and Tg(Mx1-cre)1Cgn
• accumulation of mast cells in the skin and in some cases also in the spleen
• disease symptoms occur later and disease progression is slower compared to mice carrying Tg(Kit*D814V)1Roer and Tg(Mx1-cre)1Cgn

tumorigenesis
• mast cell tumors are seen in some mice

immune system
• all mice develop intestinal inflammation similar to that in mice carrying Tg(Kit*D814V)1Roer and Tg(Mx1-cre)1Cgn
• develop mastocytosis similar to that in mice carrying Tg(Kit*D814V)1Roer and Tg(Mx1-cre)1Cgn
• accumulation of mast cells in the skin and in some cases also in the spleen
• disease symptoms occur later and disease progression is slower compared to mice carrying Tg(Kit*D814V)1Roer and Tg(Mx1-cre)1Cgn

integument
• mast cell tumors are seen in some mice

Mouse Models of Human Disease
OMIM IDRef(s)
Mast Cell Disease 154800 J:169611