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Phenotypes Associated with This Genotype
Genotype
MGI:4942363
Allelic
Composition
Tg(Cma1-cre)ARoer/0
Tg(Kit*D814V)1Roer/0
Genetic
Background
involves: C57BL/6
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phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• all mice develop intestinal inflammation similar to that in mice carrying Tg(Kit*D814V)1Roer and Tg(Mx1-cre)1Cgn

hematopoietic system
• develop mastocytosis similar to that in mice carrying Tg(Kit*D814V)1Roer and Tg(Mx1-cre)1Cgn
• accumulation of mast cells in the skin and in some cases also in the spleen
• disease symptoms occur later and disease progression is slower compared to mice carrying Tg(Kit*D814V)1Roer and Tg(Mx1-cre)1Cgn

neoplasm
• mast cell tumors are seen in some mice

immune system
• all mice develop intestinal inflammation similar to that in mice carrying Tg(Kit*D814V)1Roer and Tg(Mx1-cre)1Cgn
• develop mastocytosis similar to that in mice carrying Tg(Kit*D814V)1Roer and Tg(Mx1-cre)1Cgn
• accumulation of mast cells in the skin and in some cases also in the spleen
• disease symptoms occur later and disease progression is slower compared to mice carrying Tg(Kit*D814V)1Roer and Tg(Mx1-cre)1Cgn

integument
• mast cell tumors are seen in some mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Mast Cell Disease 154800 J:169611


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory