Phenotypes Associated with This Genotype

Genotype
MGI:4941823

• Allelic Composition: Dchs1^tm1.2Irv/Dchs1^tm1.2Irv; Fat4^tm1.1Hmc/Fat4^tm1.1Hmc
• Genetic Background: involves: 129 * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

abnormal orientation of cochlear hair cell stereociliary bundles ( J:169135 )

• mostly subtle (less than 2 degrees) differences in the average orientation of stereocilia

abnormal orientation of outer hair cell stereociliary bundles ( J:169135 )

• in the outermost row of hair cells there is a 4 degree difference in the average orientation of stereocilia

nervous system

abnormal neural tube morphology ( J:169135 )

• increase in the width to height ratio

abnormal orientation of cochlear hair cell stereociliary bundles ( J:169135 )

• mostly subtle (less than 2 degrees) differences in the average orientation of stereocilia

abnormal orientation of outer hair cell stereociliary bundles ( J:169135 )

• in the outermost row of hair cells there is a 4 degree difference in the average orientation of stereocilia

skeleton

short sternum ( J:169135 )

• shorter than normal

wide sternum ( J:169135 )

• wider than normal

abnormal thoracic vertebrae morphology ( J:169135 )

• vertebrae in the lumbar and posterior thoracic regions show a modest increase in the width and are narrower along the anterior-posterior axis

• the centrum at the midline is malformed

abnormal vertebrae development ( J:169135 )

• dual ossification centers are present in vertebrae in the lumbar and posterior thoracic regions

abnormal endochondral bone ossification ( J:169135 )

• dual ossification centers are present in vertebrae in the lumbar and posterior thoracic regions

abnormal sternum ossification ( J:169135 )

• abnormal ossification pattern

respiratory system

small lung ( J:169135 )

embryo

abnormal neural tube morphology ( J:169135 )

• increase in the width to height ratio