Phenotypes for Rag2 Trp53 MGI:4941322 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Rag2^tm1.1Desi/Rag2^tm1.1Desi Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2^tm1.1Desi mutation (0 available); any Rag2 mutation (117 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased T cell derived lymphoma incidence ( J:168974 )

• unlike in Trp53^tm1Tyj homozygotes, T cell derived lymphomas contain less mature CD4-CD8- and CD4-CD8+ intermediate single positive cells and some lymphomas exhibit chromosomal translocations

increased B cell derived lymphoma incidence ( J:168974 )

• in one fourth of mice

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:168974 )

• unlike in Trp53^tm1Tyj homozygotes, T cell derived lymphomas contain less mature CD4-CD8- and CD4-CD8+ intermediate single positive cells and some lymphomas exhibit chromosomal translocations

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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