Phenotypes Associated with This Genotype

Genotype
MGI:4941204

• Allelic Composition: Adar^tm1Olds/Adar^tm1Olds
• Genetic Background: involves: 129S/SvEv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:169014 )

• mice die at E11 to E12

immune system

increased susceptibility to Orthomyxoviridae infection ( J:169014 )

• mouse embryonic fibroblasts infected with an Orthomyxoviridae Family virus (influenza) exhibit higher titers than similarly treated wild-type cells

• however, response to infection with lymphocytic choriomeningitis virus, vesicular stomatitis virus, or reovirus is normal

increased susceptibility to Paramyxoviridae infection ( J:169014 )

• mouse embryonic fibroblasts infected with Paramyxoviridae Family viruses (measles, Newcastle disease, Sendai, and canine distemper) exhibit higher titers than similarly treated wild-type cells

cellular

abnormal cell physiology ( J:169014 )

• mouse embryonic fibroblasts infected with Paramyxoviridae Family viruses (measles, Newcastle disease, Sendai, and canine distemper) or an Orthomyxoviridae Family virus (influenza) exhibit higher titers than similarly treated wild-type cells

• however, response to infection with lymphocytic choriomeningitis virus, vesicular stomatitis virus, or reovirus is normal