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Phenotypes Associated with This Genotype
Genotype
MGI:4941177
Allelic
Composition		 Sema4btm1Akum/Sema4btm1Akum
Genetic
Background		 either: B6.Cg-Sema4btm1Akum or C.Cg-Sema4btm1Akum
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema4btm1Akum mutation (0 available); any Sema4b mutation (298 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immune system physiology ( J:169386 )
• mice exhibit enhanced memory response compared with wild-type mice
• however, deletion of basophils suppresses this enhancement
increased IgE level ( J:169386 )
• following immunization with NP-CGG or Fcer1 cross-linking
• following immunization and boost with ovalbumin
increased IgG1 level ( J:169386 )
• following immunization and boost with ovalbumin

hematopoietic system
increased IgE level ( J:169386 )
• following immunization with NP-CGG or Fcer1 cross-linking
• following immunization and boost with ovalbumin
increased IgG1 level ( J:169386 )
• following immunization and boost with ovalbumin

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory