Phenotypes Associated with This Genotype

Genotype
MGI:4941029

• Allelic Composition: Nr2c2^tm1Amj/Nr2c2^tm1Amj
• Genetic Background: B6.129-Nr2c2^tm1Amj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:169333 )

• fewer than expected mice are present at E12.5

homeostasis/metabolism

abnormal blood homeostasis ( J:169333 )

decreased circulating alanine transaminase level ( J:169333 )

• when fed standard chow or a high-fat diet

decreased circulating aspartate transaminase level ( J:169333 )

• when fed a high-fat diet

abnormal energy homeostasis ( J:169333 )

increased energy expenditure ( J:169333 )

• when fed a high-fat diet

decreased susceptibility to diet-induced obesity ( J:169333 )

• when fed a high-fat diet

abnormal gas homeostasis ( J:169333 )

increased carbon dioxide production ( J:169333 )

• when fed a high-fat diet

increased oxygen consumption ( J:169333 )

• when fed a high-fat diet

increased respiratory quotient ( J:169333 )

• when fed a high-fat diet

abnormal glucose homeostasis ( J:169333 )

• mice fed a high-fat diet retain their glucose tolerance and insulin sensitivity unlike similarly treated wild-type mice

decreased circulating glucose level ( J:169333 )

• when fed a high-fat diet

decreased circulating insulin level ( J:169333 )

• when fed a high-fat diet

abnormal lipid homeostasis ( J:169333 )

decreased circulating cholesterol level ( J:169333 )

• when fed standard chow or a high-fat diet

decreased circulating LDL cholesterol level ( J:169333 )

• when fed a high-fat diet

decreased circulating triglyceride level ( J:169333 )

decreased liver triglyceride level ( J:169333 )

• when fed standard chow or a high-fat diet

adipose tissue

decreased body fat mass ( J:169333 )

• when fed a high-fat diet

decreased brown adipose tissue mass ( J:169333 )

• when fed standard chow

decreased white fat cell size ( J:169333 )

• when fed standard chow or a high-fat diet

decreased epididymal fat pad weight ( J:169333 )

• when fed standard chow or a high-fat diet

decreased abdominal fat pad weight ( J:169333 )

• when fed standard chow or a high-fat diet

abnormal white adipose tissue physiology ( J:169333 )

• when fed a high-fat diet, mice exhibit reduced inflammation in white adipose tissue compared with similarly treated wild-type mice

growth/size/body

decreased body fat mass ( J:169333 )

• when fed a high-fat diet

decreased body weight ( J:169333 )

• slightly at 2 to 3 months when fed a standard chow

• at 1 year of age when fed a standard chow

• whether fed a high-fat diet

decreased susceptibility to diet-induced obesity ( J:169333 )

• when fed a high-fat diet

liver/biliary system

decreased liver triglyceride level ( J:169333 )

• when fed standard chow or a high-fat diet

decreased susceptibility to age-related hepatic steatosis ( J:169333 )

decreased susceptibility to diet-induced hepatic steatosis ( J:169333 )

behavior/neurological

abnormal eating behavior ( J:169333 )

• when fed standard chow

immune system

decreased inflammatory response ( J:169333 )

• when fed a high-fat diet, mice exhibit reduced inflammation in white adipose tissue compared with similarly treated wild-type mice