Phenotypes Associated with This Genotype

Genotype
MGI:4940059

• Allelic Composition: Tg(Prnp-ATXN3*79Q)#Hlw/0
• Genetic Background: FVB/N-Tg(Prnp-ATXN3*79Q)#Hlw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired righting response ( J:138381 )

• at 8 months

ataxia ( J:138381 )

impaired coordination ( J:138381 )

• at 7 to 8 months on a rotarod

abnormal posture ( J:138381 )

• at 10 months, mice exhibit pelvic elevation and hunched back unlike wild-type mice

hunched posture ( J:138381 )

• at 10 months

abnormal gait ( J:138381 )

• wide-based gait at 7 months

• dragging gait at 12 months

decreased locomotor activity ( J:138381 )

• at 8 months, mice exhibit reduced locomotor activity compared with wild-type mice

nervous system

nervous system phenotype ( J:138381 )

N • mice do not exhibit prominent neuronal loss in the cerebellum

neuronal intranuclear inclusions ( J:138381 )

• in neurons of the dentate nucleus

growth/size/body

decreased body weight ( J:138381 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Machado-Joseph disease		DOID:1440	OMIM:109150	J:138381