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Phenotypes Associated with This Genotype
Genotype
MGI:4940051
Allelic
Composition
Atp7aMo-ms/Y
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp7aMo-ms mutation (0 available); any Atp7a mutation (74 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
(J:168658)
(J:168658)
(J:168658)
(J:168658)
(J:168658)
(J:168658)

homeostasis/metabolism
• mice exhibit increased copper levels in the kidney but decreased copper levels in the brain and liver compared with wild-type mice (J:168658)
• mice exhibit increased copper levels in the kidney but decreased copper levels in the brain and liver compared with wild-type mice (J:168658)
(J:168658)
(J:168658)
(J:168658)
(J:168658)
(J:168658)
(J:168658)

integument
(J:15062)
(J:15062)
• mice exhibit abnormal pigmentation and hair structure of the vibrissae compared with wild-type mice (J:15062)
• mice exhibit abnormal pigmentation and hair structure of the vibrissae compared with wild-type mice (J:15062)
(J:15062)
(J:15062)

liver/biliary system
(J:168658)
(J:168658)

mortality/aging
• mice die between 2 and 3 weeks of age (J:15062)
• mice die between 2 and 3 weeks of age (J:15062)

nervous system
• arcuate nucleus growth hormone-releasing hormone (GHRH) neurons exhibit morphological changes associated with apoptosis unlike in wild-type mice (J:157286)
• arcuate nucleus growth hormone-releasing hormone (GHRH) neurons exhibit morphological changes associated with apoptosis unlike in wild-type mice (J:157286)
(J:168658)
(J:168658)

pigmentation
(J:15062)
(J:15062)

cellular
• arcuate nucleus growth hormone-releasing hormone (GHRH) neurons exhibit morphological changes associated with apoptosis unlike in wild-type mice (J:157286)
• arcuate nucleus growth hormone-releasing hormone (GHRH) neurons exhibit morphological changes associated with apoptosis unlike in wild-type mice (J:157286)

Mouse Models of Human Disease
OMIM ID Ref(s)
Menkes Disease 309400 J:168658


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory