About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4939781
Allelic
Composition
Prkntm1Ccs/Prkntm1Ccs
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkntm1Ccs mutation (1 available); any Prkn mutation (53 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• almost all mesencephalic glial cell types exhibit a higher number of structurally altered mitochondria, showing disintegration and reduction of mitochondrial cristae, mitochondrial enlargement and formation of protrusions or disruption of the outer membrane
• mitochondrial damage is noticeable at 16 days of age in all mesencephalic cell types and increases 4-8 fold in the next few weeks
• mitochondrial alterations are higher in oligodendrocytes than in astrocytes or microglia

nervous system
• almost all mesencephalic glial cell types exhibit a higher number of structurally altered mitochondria
• mitochondrial alterations are higher in oligodendrocytes than in astrocytes or microglia
• mesencephalic glial cells exhibit a higher (2.5-7-fold) percentage of damaged mitochondria than in mesencephalic neurons at 3 and 12-15 months of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Parkinson's disease 2 DOID:0060368 OMIM:600116
J:168847


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory