Phenotypes Associated with This Genotype

Genotype
MGI:4889096

• Allelic Composition: Shh^tm2Amc/Shh^tm2.1Amc; Tg(Nr5a1-cre)2Klp/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal adrenal gland morphology ( J:168522 )

• adrenal glands exhibit a decrease in stem/precursor cells compared with wild-type mice

abnormal adrenocortical cell morphology ( J:168522 )

• the number of adrenocortical cells is decreased while their size is increased compared to in wild-type mice

enlarged adrenocortical cells ( J:168522 )

thin adrenal cortex ( J:168522 )

small adrenal glands ( J:168522 )

• at P5

abnormal adrenal gland physiology ( J:168522 )

• at E16.5 and P5, adrenal gland cells exhibit reduced proliferation compared with wild-type cells

homeostasis/metabolism

decreased circulating corticosterone level ( J:168522 )

• at P21

increased circulating adrenocorticotropin level ( J:168522 )