Phenotypes Associated with This Genotype

Genotype
MGI:4889074

• Allelic Composition: Emx2^wndr/Emx2^wndr; Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw
• Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:168258 )

• mice die within a few hours of birth

nervous system

abnormal axon extension ( J:168258 )

• thalamocortical axons exhibit severe ventral misrouting near the diencephalon-telencephalon boundary on the ventral surface compared with wild-type mice

abnormal cerebral cortex morphology ( J:168258 )

• small and misshapen

small olfactory bulb ( J:168258 )

• small and misshapen

renal/urinary system

renal hypoplasia ( J:168258 )

cellular

abnormal axon extension ( J:168258 )

• thalamocortical axons exhibit severe ventral misrouting near the diencephalon-telencephalon boundary on the ventral surface compared with wild-type mice