Phenotypes Associated with This Genotype

Genotype
MGI:4889070

• Allelic Composition: Hdac3^tm1.1Laz/Hdac3^tm1.1Laz
• Genetic Background: C57BL/6-Hdac3^tm1.1Laz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

enhanced long-term object recognition memory ( J:168224 )

• 2 weeks after bilateral intrahippocampal infusion of adenoviral cre mice display enhanced long term memory for object location, forming memories following a 3 min training period that persist for up to 7 days

• however, no difference is detected in novel object recognition

• treatment with an siRNA for Nr4a2 blocks enhanced memory formation in adenoviral cre treated mice