Phenotypes Associated with This Genotype

Genotype
MGI:4889054

• Allelic Composition: Gnao1^tm3Lbi/Gnao1^tm3Lbi
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased insulin secretion ( J:168245 )

• enhanced release of insulin by isolated pancreatic islets when stimulated with glucose

• somatostatin does not suppress insulin release stimulated by glucose

decreased circulating glucose level ( J:168245 )

• fasting glucose levels are lower than controls

improved glucose tolerance ( J:168245 )

• peak blood glucose levels are lower in a glucose tolerance test and a faster decline back to baseline occurs

abnormal hormone level ( J:168245 )

• insulin content of the pancreas is about 69% of control levels

• insulin content of the Islets of Langerhans is about 70% of controls

increased circulating insulin level ( J:168245 )

• much greater blood insulin levels within 20 minutes of glucose administration

• hyperinsulinemia

• enhanced release of insulin by isolated pancreatic islets when stimulated with glucose

• somatostatin does not suppress insulin release stimulated by glucose

endocrine/exocrine glands

increased insulin secretion ( J:168245 )

• enhanced release of insulin by isolated pancreatic islets when stimulated with glucose

• somatostatin does not suppress insulin release stimulated by glucose