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Phenotypes Associated with This Genotype
Genotype
MGI:4888251
Allelic
Composition
Myh10tm2Rsad/Myh10tm2Rsad
Myh14tm1Rsad/Myh14tm1Rsad
Genetic
Background
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myh10tm2Rsad mutation (1 available); any Myh10 mutation (95 available)
Myh14tm1Rsad mutation (1 available); any Myh14 mutation (81 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• embryos die as a result of cardiomyopathy after E14.5

cellular
• cardiomyocytes show an increase in acetylated tubulin staining suggesting an increase in microtubule stability
• at E13.5, gamma-tubulin staining showed abnormal formation of multiple centrosomes in mitotic cardiac myocytes
• cardiomyocytes exhibit impaired karyokinesis and multiple centrosomes
• mitotic cardiomyocytes lack a bipolar spindle at metaphase; instead, spindles are deformed with irregular aggregated chromosomes

cardiovascular system
• at E13.5, 91% of cardiomyocytes exhibit an abnormal shape
• 9% of cardiomyocytes are binucleated
• nuclei are irregular and significantly larger, sometimes exhibiting a multilobed appearance
• mitotic cardiomyocytes lack a bipolar spindle; instead, spindles are deformed with irregular aggregated chromosomes
• however, sarcomere formation is normal in E13.5 cardiac myocytes
• at E13.5, hearts exhibit a marked reduction in cardiomyocytes
• embryonic heart is severely hypoplastic; however, numbers of cardiac myocytes are sufficient to support life to E14.5

muscle


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory