Mouse Genome Informatics
tg
    Tg(Plp)66Kan/0
B6NCrl.Cg-Tg(Plp)66Kan
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
• at 15-18 months of age, mutants develop ataxia

growth/size
• at 15-18 months of age, mutants begin to lose weight

nervous system
• slightly thinner myelin sheath
• mice show demyelination starting from 15-18 months of age
• older mice exhibit axonal degeneration preferentially affecting smaller diameter fibers

skeleton
• at 15-18 months of age, mutants develop kyphosis

Mouse Models of Human Disease
OMIM IDRef(s)
Pelizaeus-Merzbacher Disease; PMD 312080 J:156106