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Phenotypes Associated with This Genotype
Genotype
MGI:4887901
Allelic
Composition
Tg(Plp)66Kan/0
Genetic
Background
B6NCrl.Cg-Tg(Plp)66Kan
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• at 15-18 months of age, mutants develop ataxia

growth/size/body
• at 15-18 months of age, mutants begin to lose weight

nervous system
• slightly thinner myelin sheath
• older mice exhibit axonal degeneration preferentially affecting smaller diameter fibers
• mice show demyelination starting from 15-18 months of age

skeleton
• at 15-18 months of age, mutants develop kyphosis

Mouse Models of Human Disease
OMIM ID Ref(s)
Pelizaeus-Merzbacher Disease; PMD 312080 J:156106


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory