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Phenotypes Associated with This Genotype
Genotype
MGI:4882073
Allelic
Composition		 Perptm2Att/Perptm2Att
Tg(KRT14-cre/ERT2)1Ipc/0
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Perptm2Att mutation (1 available); any Perp mutation (9 available)
Tg(KRT14-cre/ERT2)1Ipc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
decreased keratinocyte apoptosis ( J:167545 )
• in tamoxifen- and UVB-treated mice
skin inflammation ( J:167545 )
• in tamoxifen- and UVB-treated mice
increased skin squamous cell carcinoma incidence ( J:167545 )
• tamoxifen- and UVB-treated mice exhibit reduced latency to development of squamous cell and increased number of tumors per mouse compared with similarly treated wild-type mice

neoplasm
increased skin squamous cell carcinoma incidence ( J:167545 )
• tamoxifen- and UVB-treated mice exhibit reduced latency to development of squamous cell and increased number of tumors per mouse compared with similarly treated wild-type mice
decreased tumor latency ( J:167545 )
• tamoxifen-treated mice exhibit reduced latency to development of squamous cell carcinomas induced by UVB irradiation compared with similarly treated wild-type mice

immune system
skin inflammation ( J:167545 )
• in tamoxifen- and UVB-treated mice

cellular
decreased keratinocyte apoptosis ( J:167545 )
• in tamoxifen- and UVB-treated mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory