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Phenotypes Associated with This Genotype
Genotype
MGI:4882058
Allelic
Composition		 Pnpt1tm1Teit/Pnpt1tm1Teit
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pnpt1tm1Teit mutation (0 available); any Pnpt1 mutation (40 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal mitochondrial crista morphology ( J:167932 )
• mitochondria in liver cells exhibit disordered circular and smooth IM cristae compared to in wild-type cells
abnormal mitochondrial physiology ( J:167932 )
• mitochondria in liver cells exhibit inefficient mtRNA precursor processing and impaired RNA import compared to in wild-type cells
abnormal mitochondrial ATP synthesis coupled electron transport ( J:167932 )
• mitochondria in liver cells exhibit a 1.5- to 2-fold decrease in activity of Complex IV and Complexes II+III+IV compared to in wild-type cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory