cardiovascular system
• morphological changes observed 3 weeks after transverse cardiac constriction are reduced to levels observed in controls when treated with histone deacetylase inhibitors
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• heart weight/body weight ratio shows a significantly greater increase than in controls 3 weeks after transverse cardiac constriction
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• observed histologically 3 weeks after transverse cardiac constriction
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• increased left ventricular diameter during systole
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• severe 3 weeks after transverse cardiac constriction
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• heart function improves after treatment with histone deacetylase inhibitors
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• defective contractility on electrical stimulation
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• decreased left ventricular fractional shortening
• also observed in explanted heart Langendorff preparations treated with isoproterenol
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• impaired generation of left ventricular pressure in Langendorff preparations treated with isoproterenol
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muscle
• defective contractility on electrical stimulation
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• decreased left ventricular fractional shortening
• also observed in explanted heart Langendorff preparations treated with isoproterenol
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growth/size/body
• heart weight/body weight ratio shows a significantly greater increase than in controls 3 weeks after transverse cardiac constriction
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• observed histologically 3 weeks after transverse cardiac constriction
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