Phenotypes Associated with This Genotype

Genotype
MGI:4881768

• Allelic Composition: Mylk3^tm1Jtst/Mylk3^tm1Jtst
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Mylk3^tm1Jtst/Mylk3⁺ and Mylk3^tm1Jtst/Mylk3^tm1Jtst mice exhibit hypertrophic hearts

cardiovascular system

increased myocardial fiber size ( J:167590 )

heart right ventricle hypertrophy ( J:167590 )

thick interventricular septum ( J:167590 )

• in untreated and isoproterenol treated mice

increased heart weight ( J:167590 )

abnormal heart left ventricle morphology ( J:167590 )

• mice exhibit increased left ventricular end-systolic and end-diastolic dimensions compared with wild-type mice

heart left ventricle hypertrophy ( J:167590 )

increased heart left ventricle weight ( J:167590 )

• in untreated and isoproterenol treated mice

cardiac interstitial fibrosis ( J:167590 )

• in the ventricle, but not atria, at 19 to 22 weeks

decreased cardiac muscle contractility ( J:167590 )

muscle

increased myocardial fiber size ( J:167590 )

heart left ventricle hypertrophy ( J:167590 )

heart right ventricle hypertrophy ( J:167590 )

decreased cardiac muscle contractility ( J:167590 )

growth/size/body

heart left ventricle hypertrophy ( J:167590 )

heart right ventricle hypertrophy ( J:167590 )

increased heart weight ( J:167590 )

cellular

cardiac interstitial fibrosis ( J:167590 )

• in the ventricle, but not atria, at 19 to 22 weeks