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Phenotypes Associated with This Genotype
Genotype
MGI:4881338
Allelic
Composition
Foxp3sf/Y
Genetic
Background
B6.Cg-Foxp3sf
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3sf mutation (6 available); any Foxp3 mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• mutants exhibit about 4-fold less mature bone marrow megakaryocytes than controls
• mutants exhibit about a 50% reduction in megakaryocyte progenitors
• mutants exhibit up to 53% fewer platelets than controls
• at 10 days of age there are significantly fewer CD4+ CD25+ T cells in the lymph nodes and thymus compared with controls and transfer of CD4+ CD25+ T cells from wild-type donors into 1- to 2-day old hemizygous pups rescues the disease phenotype
• CD4+ CD25+ T cells from 28 day old lymph nodes proliferate abnormally in response to TCR stimulation and fail to provide suppressor activity
• transfer of CD4+ T cells from hemizygotes into RAG1 deficient hosts transfers the wasting disease and colitis and co-transfer of CD4+ CD25+ from wild-type donors prevents the development of this disease

homeostasis/metabolism
• mutants exhibit reduced serum levels of TGF-beta and increased serum levels of CD40L, TXB2, and 12(S)-HETE, suggesting altered platelet release

immune system
• at 10 days of age there are significantly fewer CD4+ CD25+ T cells in the lymph nodes and thymus compared with controls and transfer of CD4+ CD25+ T cells from wild-type donors into 1- to 2-day old hemizygous pups rescues the disease phenotype
• CD4+ CD25+ T cells from 28 day old lymph nodes proliferate abnormally in response to TCR stimulation and fail to provide suppressor activity
• transfer of CD4+ T cells from hemizygotes into RAG1 deficient hosts transfers the wasting disease and colitis and co-transfer of CD4+ CD25+ from wild-type donors prevents the development of this disease


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/05/2019
MGI 6.13
The Jackson Laboratory