Mouse Genome Informatics
ht
    Fbn1tm1Lper/Fbn1+
involves: 129/Sv * C57BL/6 * CD-1
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
cardiovascular system
• at 9 months, aortic media is thickened compared to in wild-type mice
• Background Sensitivity: however, mice on a C57BL/6 congenic background are asymptomatic at 3 months unlike mice on a 129/Sv congenic background

respiratory system
• Background Sensitivity: at 3 months, expanded alveoli in mice on a C57BL/6 congenic background are milder than in mice on a 129/Sv congenic background
• at 6 months, mice exhibit severely expanded alveoli compared with wild-type mice

skeleton
• Background Sensitivity: skeletal manifestations (measured by ratio between the linear distance and the length from the first cervical vertebrae to the last thoracic vertebrae) in mice on a C57BL/6 congenic background are milder than in mice on a 129/Sv congenic background

Mouse Models of Human Disease
OMIM IDRef(s)
Marfan Syndrome; MFS 154700 J:167276