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Phenotypes Associated with This Genotype
Genotype
MGI:4880671
Allelic
Composition
Fbn1tm1Lper/Fbn1+
Genetic
Background
involves: 129/Sv * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbn1tm1Lper mutation (0 available); any Fbn1 mutation (77 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• at 9 months, aortic media is thickened compared to in wild-type mice
• Background Sensitivity: however, mice on a C57BL/6 congenic background are asymptomatic at 3 months unlike mice on a 129/Sv congenic background

respiratory system
• Background Sensitivity: at 3 months, expanded alveoli in mice on a C57BL/6 congenic background are milder than in mice on a 129/Sv congenic background
• at 6 months, mice exhibit severely expanded alveoli compared with wild-type mice

skeleton
• Background Sensitivity: skeletal manifestations (measured by ratio between the linear distance and the length from the first cervical vertebrae to the last thoracic vertebrae) in mice on a C57BL/6 congenic background are milder than in mice on a 129/Sv congenic background

Mouse Models of Human Disease
OMIM ID Ref(s)
Marfan Syndrome; MFS 154700 J:167276


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory