Phenotypes Associated with This Genotype

Genotype
MGI:4868621

• Allelic Composition: Cars2^m1Btlr/Cars2^m1Btlr
• Genetic Background: C57BL/6J-Cars2^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

tremors ( J:167594 )

• several months after onset of hyperactivity at ~ 5 months of age, mice develop tremors

head bobbing ( J:167594 )

• several months after onset of the hyperactive phenotype at ~ 5 months of age, mice develop head-bobbing behavior

induced hyperactivity ( J:167594 )

• at 5 months of age, mice homozygous for this mutation exhibit horizontal hyperactivity, especially when handled or placed in a new cage environment; this behavior becomes more pronounced and prolonged over time, peaking at about 9 months

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:167594 )

N • neither 2 nor 6 month old mutant mice exhibit hearing loss, as assessed by auditory brainstem response (ABR) and distortion product autoacoustic emission (DPOAE)

nervous system

nervous system phenotype ( J:167594 )

N • histological examination of hematoxylin/eosin-stained brains of homozygous mice reveals no structural abnormalities