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Phenotypes Associated with This Genotype
Genotype
MGI:4868583
Allelic
Composition
Lmnatm8Lgf/Lmnatm8Lgf
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm8Lgf mutation (0 available); any Lmna mutation (61 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice exhibit normal survival (J:167229)
• mice exhibit normal survival (J:167229)

cardiovascular system
• at 12 months, mice exhibit slightly reduced left ventricular posterior wall thickness compared to in wild-type mice (J:167229)
• at 12 months, mice exhibit slightly reduced left ventricular posterior wall thickness compared to in wild-type mice (J:167229)
• slightly at 12 months (J:167229)
• slightly at 12 months (J:167229)

cellular
• misshapen with blebs in fibroblasts and rarely in liver cells (J:167229)
• misshapen with blebs in fibroblasts and rarely in liver cells (J:167229)

adipose tissue
N
• mice exhibit normal body fat (J:167229)
• mice exhibit normal body fat (J:167229)

growth/size/body
N
• mice exhibit normal body weight curves (J:167229)
• mice exhibit normal body weight curves (J:167229)

skeleton
N
• mice exhibit normal bone density (J:167229)
• mice exhibit normal bone density (J:167229)

muscle
• slightly at 12 months (J:167229)
• slightly at 12 months (J:167229)

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Hutchinson-Gilford Progeria Syndrome; HGPS 176670 J:167229


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory