Mouse Genome Informatics
ht
    Prkar1atm1.1Lsk/Prkar1a+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
skeleton
• overall bone mineralization density is lower than in wild-type mice

tumorigenesis
• heterozygotes develop bone lesions derived from camp-responsive osteogenic cells and resemble fibrous dysplasia
• about 50% of mutants develop osteomyoxomas in the caudal vertebrae by 8 months of age, with 100% of mice showing these by one year
• rare development of metastatic osteochondrosarcomas

Mouse Models of Human Disease
OMIM IDRef(s)
Carney Complex, Type 1; CNC1 160980 J:160299