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Phenotypes Associated with This Genotype
Genotype
MGI:4868217
Allelic
Composition
Prkar1atm1.1Lsk/Prkar1a+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkar1atm1.1Lsk mutation (0 available); any Prkar1a mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system

endocrine/exocrine glands

skeleton
• heterozygotes develop bone lesions derived from camp-responsive osteogenic cells and resemble fibrous dysplasia
• about 50% of mutants develop osteomyoxomas in the caudal vertebrae by 8 months of age, with 100% of mice showing these by one year
• rare development of metastatic osteochondrosarcomas
• overall bone mineralization density is lower than in wild-type mice

neoplasm
• heterozygotes develop bone lesions derived from camp-responsive osteogenic cells and resemble fibrous dysplasia
• about 50% of mutants develop osteomyoxomas in the caudal vertebrae by 8 months of age, with 100% of mice showing these by one year
• rare development of metastatic osteochondrosarcomas

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Carney complex DOID:0050471 OMIM:160980
OMIM:605244
OMIM:608837
J:160299


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/15/2022
MGI 6.22
The Jackson Laboratory