Phenotypes Associated with This Genotype

Genotype
MGI:4867064

• Allelic Composition: Slc8a1^m51207Hubr/Slc8a1^m51207Hubr
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:167034 )

• around E10

cardiovascular system

absent vitelline blood vessels ( J:167034 )

• mice lack a blood-filled vasculature in the yolk sac unlike wild-type mice

abnormal heart tube morphology ( J:167034 )

• at E9.5 to E10.5, mice exhibit abnormal folding of the heart tube unlike in wild-type mice

abnormal cardiovascular system physiology ( J:167034 )

• cardiomyocytes derived from E9.5 embryos fibrillate and contract randomly unlike cultured wild-type cells

• calcium ions from cultured cardiomyocytes exhibit smaller amplitude and lower frequency compared with wild-type cells

absent heartbeat ( J:167034 )

embryo

absent vitelline blood vessels ( J:167034 )

• mice lack a blood-filled vasculature in the yolk sac unlike wild-type mice

abnormal pharyngeal arch morphology ( J:167034 )

• at E9.5 to E10.5, branchial arches are dilated compared to in wild-type mice

enlarged first pharyngeal arch ( J:167034 )

• at E9.5 to E10.5

absent placenta hemotrichorial membrane ( J:167034 )

• mice lack the hemotrichorial layer unlike in wild-type mice

absent placental labyrinth ( J:167034 )

homeostasis/metabolism

edema ( J:167034 , J:173681 )

• extreme thoracic edema at E9.5 (J:167034)

• cardiac edema (J:173681)

craniofacial

abnormal pharyngeal arch morphology ( J:167034 )

• at E9.5 to E10.5, branchial arches are dilated compared to in wild-type mice

enlarged first pharyngeal arch ( J:167034 )

• at E9.5 to E10.5