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Phenotypes Associated with This Genotype
Genotype
MGI:4848149
Allelic
Composition
Dnm2tm1.1Ics/Dnm2+
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnm2tm1.1Ics mutation (0 available); any Dnm2 mutation (85 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• resting cytosolic calcium level is about 50% higher in extensor digitorum longus (EDL) muscle fibers, but not in soleus muscle
• sarcolemmal permeability to calcium is increased and sarcoplasmic reticulum calcium content is higher in EDL
• however, calcium-transient characteristics are unchanged in EDL

muscle
• mice exhibit intermyofibrillar disorganization compared with wild-type mice
• beginning at 2 months and increasing in prevalence with age, muscle fibers exhibit centrally localization of mitochondria and sarcoplasmic reticulum within unlike in wild-type muscle
• slightly at 2 months and significantly at 8 months in the tibialis anterior and quadriceps
• at 2 months and increasing in prevalence with age
• in the soleus between 2 and 8 months
• in the quadriceps at 8 months
• in the gastrocnemius and plantaris at 8 months
• in the tibialis anterior at 2 and 8 months
• muscle mass in the soleus and diaphragm is transiently increased compared to in wild-type mice
• beginning at 2 months and worse at 8 months
• muscle fiber tetanic force is reduced in EDL
• at 3 weeks of age in the tibialis anterior and soleus


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory