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Phenotypes Associated with This Genotype
Genotype
MGI:4847969
Allelic
Composition
Lrp2m267Asp/Lrp2m267Asp
Genetic
Background
involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp2m267Asp mutation (0 available); any Lrp2 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• performance on the rotarod task is indistinguishable from controls when fed a selenium-adequate diet, however when mutants are fed a low-selenium diet for 4 weeks after weaning, mice exhibit impaired movement coordination on the rotarod (J:166387)
• performance on the rotarod task is indistinguishable from controls when fed a selenium-adequate diet, however when mutants are fed a low-selenium diet for 4 weeks after weaning, mice exhibit impaired movement coordination on the rotarod (J:166387)

homeostasis/metabolism
• serum selenium levels are reduced irrespective of the food selenium content (J:166387)
• levels of serum selenoprotein P are reduced (J:166387)
• serum selenium levels are reduced irrespective of the food selenium content (J:166387)
• levels of serum selenoprotein P are reduced (J:166387)
• urinary selenium content is increased while serum selenium levels are reduced (J:166387)
• with adequate dietary selenium intake, renal selenium content is not significantly changed in mutants, however upon dietary selenium restriction, renal selenium content is significantly reduced in mutants (J:166387)
• selenium levels in liver and brain are reduced (J:166387)
• urinary selenium content is increased while serum selenium levels are reduced (J:166387)
• with adequate dietary selenium intake, renal selenium content is not significantly changed in mutants, however upon dietary selenium restriction, renal selenium content is significantly reduced in mutants (J:166387)
• selenium levels in liver and brain are reduced (J:166387)
• selenoprotein P (SePP) is present in urine of mutants but not wild-type mice (J:166387)
• selenoprotein P (SePP) is present in urine of mutants but not wild-type mice (J:166387)
• urinary selenium content is increased (J:166387)
• urinary selenium content is increased (J:166387)
• activity of the selenoenzyme glutathione peroxidase (GPx) is reduced in the plasma, in the brain, kidney, and liver (J:166387)
• activity of the selenoenzyme glutathione peroxidase (GPx) is reduced in the plasma, in the brain, kidney, and liver (J:166387)

nervous system
• mild exencephaly (J:166387)
• mild exencephaly (J:166387)

renal/urinary system
• selenoprotein P (SePP) is present in urine of mutants but not wild-type mice (J:166387)
• selenoprotein P (SePP) is present in urine of mutants but not wild-type mice (J:166387)
• urinary selenium content is increased (J:166387)
• urinary selenium content is increased (J:166387)

Mouse Models of Human Disease
OMIM ID Ref(s)
Donnai-Barrow Syndrome 222448 J:166387


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory