Mouse Genome Informatics
hm
    Lrp2m267Asp/Lrp2m267Asp
involves: C57BL/6J * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
• performance on the rotarod task is indistinguishable from controls when fed a selenium-adequate diet, however when mutants are fed a low-selenium diet for 4 weeks after weaning, mice exhibit impaired movement coordination on the rotarod

homeostasis/metabolism
• serum selenium levels are reduced irrespective of the food selenium content
• levels of serum selenoprotein P are reduced
• urinary selenium content is increased while serum selenium levels are reduced
• with adequate dietary selenium intake, renal selenium content is not significantly changed in mutants, however upon dietary selenium restriction, renal selenium content is significantly reduced in mutants
• selenium levels in liver and brain are reduced
• selenoprotein P (SePP) is present in urine of mutants but not wild-type mice
• urinary selenium content is increased
• activity of the selenoenzyme glutathione peroxidase (GPx) is reduced in the plasma, in the brain, kidney, and liver

nervous system
• mild exencephaly

renal/urinary system
• selenoprotein P (SePP) is present in urine of mutants but not wild-type mice
• urinary selenium content is increased

Mouse Models of Human Disease
OMIM IDRef(s)
Donnai-Barrow Syndrome 222448 J:166387