Phenotypes for Aplp2 App MGI:4847598 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Aplp2^tm1Dbo/Aplp2^tm1Dbo App^tm3.1Zhe/App^tm3.1Zhe
Genetic Background	involves: 129/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aplp2^tm1Dbo mutation (1 available); any Aplp2 mutation (31 available)
App^tm3.1Zhe mutation (0 available); any App mutation (118 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Neuromuscular synapse defects in App^tm3.1Zhe/App^tm3.1Zhe Aplp2^tm1Dbo/Aplp2^tm1Dbo mice

mortality/aging

postnatal lethality, incomplete penetrance ( J:166379 )

• although born in Mendelian ratios, few mice survive to adulthood

nervous system

abnormal neuromuscular synapse morphology ( J:166379 )

• neuromuscular junction exhibit mislocalization of choline transporters compared with wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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