vision/eye
• eye defects are seen as early as E10.5
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• by E11.5, abnormal development of the eyes is seen with anterior expansion of the retinal pigmented epithelium
• the anterior movement of the retinal pigmented epithelium results in an iris with a bowtie-like appearance
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• eyes at 3 weeks of age show iris hyperplasia
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• cornea edema
• severity of cornea defects in the eyes vary among animals
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• eyes at 3 weeks of age show iridocorneal adhesion
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• eyes at 3 weeks after birth have thickened corneas
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• eyes have only a single layer of cornea epithelium cell
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• corneal thickness is increased mainly in the stromal layer
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• the lens is pushed toward the cornea by overproliferated retina and mesenchyme tissues
• severity of lens defects in the eyes vary among animals
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small lens
(
J:184697
)
• eyes at 3 weeks of age have a smaller lens in the anterior segment
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• by E11.5, abnormal development of the eyes is seen with anterior expansion of the retinal pigmented epithelium
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• the lens vesicle at E10.5 is smaller and incompletely developed
• the lens vesicle is compressed by the invading periocular mesenchyme
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• optic vesicle at E10.5 is larger than in wild-type mice
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• enucleated eyes of mutants at 3 months of age are microphthalmic and about 50% smaller in size than wild-type eyes
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• smaller palpebral fissure
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retina fold
(
J:184697
)
• folding of the retina
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• presence of ectopic pigmented tissue in the vitreous
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pigmentation
• by E11.5, abnormal development of the eyes is seen with anterior expansion of the retinal pigmented epithelium
• the anterior movement of the retinal pigmented epithelium results in an iris with a bowtie-like appearance
|