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Phenotypes Associated with This Genotype
Genotype
MGI:4844277
Allelic
Composition
Flt1tm1Jrt/Flt1tm1Jrt
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt1tm1Jrt mutation (1 available); any Flt1 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
• only large fused vessels with internally localized groups of endothelial cells are present in the head mesenchyme instead of the small vessels observed in wild-type mice
• contains endothelial cells within the lumen
• vascular structures are large and enclosed with endothelial cells compared to in wild-type mice
• however, endothelial cell formation is normal
• the endocardial lining of heart ventricles are thickened and disorganized compared to in wild-type mice

embryo
• vascular structures are large and enclosed with endothelial cells compared to in wild-type mice
• however, endothelial cell formation is normal
• blood-island structures are abnormal and disorganized compared to in wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory