Analysis Tools
behavior/neurological
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• 7 of 9 mutants treated with kainic acid (KA) to induce seizures, develop at least two spontaneous seizures that qualify as epilepsy
• mutants treated with KA to induce seizures exhibit a shorter latency to onset of seizures
• mutants treated with pentylenetretrazol (PTZ) to induce seizures exhibit a significantly shorter latency to onset of seizures than controls but exhibit a similar number of acute seizures as controls
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• 14 of 273 mice exhibit random handling-induced seizures
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muscle
nervous system
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• moderate decrease in dendritic branching and total dendritic length of CA1 pyramidal cells
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• N type and D type spines are increased 11% compared to CA1 neurons from wild-type
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• mutants exhibit enhanced excitability in the hippocampus as indicated by an increase in population spike (PS) amplitude
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• 7 of 9 mutants treated with kainic acid (KA) to induce seizures, develop at least two spontaneous seizures that qualify as epilepsy
• mutants treated with KA to induce seizures exhibit a shorter latency to onset of seizures
• mutants treated with pentylenetretrazol (PTZ) to induce seizures exhibit a significantly shorter latency to onset of seizures than controls but exhibit a similar number of acute seizures as controls
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• 14 of 273 mice exhibit random handling-induced seizures
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• short-term plasticity is altered as indicated by a decrease in the facilitation of the secondary population spike (PS) elicited during the 7 Hz stimulation train
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