Mouse Genome Informatics
cx
    Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-Gnas)1593Mpke/0

B6.Cg-Tg(Camk2a-tTA)1Mmay Tg(tetO-Gnas)1593Mpke
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• in mice never fed doxycycline or fed doxycycline only during development or only during adulthood
• mice never fed doxycycline or fed doxycycline only during development or only during adulthood exhibit a decrease in dorsal striatum compared with wild-type mice
• mice never fed doxycycline or fed doxycycline only during development or only during adulthood exhibit a decrease in ventral striatum compared with wild-type mice
• in mice never fed doxycycline but not mice fed doxycycline during adulthood only
• mice that never received doxycycline exhibit decreased prepulse inhibition compared with wild-type mice
• however, mice that receive doxycycline throughout development or only in adulthood or are treated with haloperidol exhibit normal prepulse inhibition
• in mice never fed doxycycline but not mice fed doxycycline during adulthood only

behavior/neurological
N
• mice exhibit no change in anxiety-related behavior (J:166114)
• mice never fed doxycycline exhibit impaired short-term and long-term memory for hippocampus-dependent contextual fear compared with wild-type mice
• mice fed doxycycline only during adulthood or only during the retrieval but not training exhibit reduced levels of contextual fear 24 hours following training compared with wild-type mice
• however, mice fed doxycycline only during development or only after training through retrieval exhibit normal long-term memory for contextual fear
• mice never fed doxycycline or only fed doxycycline during development but not during adulthood only exhibit impaired spatial learning in a Morris water maze compared with wild-type mice
• mice never fed doxycycline or only fed doxycycline during development or during adulthood only exhibit impaired spatial memory in a Morris water maze compared with wild-type mice
• in mice never fed doxycycline or only fed doxycycline during adulthood but not during development only

Mouse Models of Human Disease
OMIM IDRef(s)
Schizophrenia; SCZD 181500 J:166114