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Phenotypes Associated with This Genotype
Genotype
MGI:4843272
Allelic
Composition
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-Gnas)1593Mpke/0
Genetic
Background
B6.Cg-Tg(Camk2a-tTA)1Mmay Tg(tetO-Gnas)1593Mpke
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Camk2a-tTA)1Mmay mutation (8 available)
Tg(tetO-Gnas)1593Mpke mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• in mice never fed doxycycline or fed doxycycline only during development or only during adulthood
• mice never fed doxycycline or fed doxycycline only during development or only during adulthood exhibit a decrease in dorsal striatum compared with wild-type mice
• mice never fed doxycycline or fed doxycycline only during development or only during adulthood exhibit a decrease in ventral striatum compared with wild-type mice
• in mice never fed doxycycline but not mice fed doxycycline during adulthood only
• mice that never received doxycycline exhibit decreased prepulse inhibition compared with wild-type mice
• however, mice that receive doxycycline throughout development or only in adulthood or are treated with haloperidol exhibit normal prepulse inhibition
• in mice never fed doxycycline but not mice fed doxycycline during adulthood only

behavior/neurological
N
• mice exhibit no change in anxiety-related behavior
• mice never fed doxycycline exhibit impaired short-term and long-term memory for hippocampus-dependent contextual fear compared with wild-type mice
• mice fed doxycycline only during adulthood or only during the retrieval but not training exhibit reduced levels of contextual fear 24 hours following training compared with wild-type mice
• however, mice fed doxycycline only during development or only after training through retrieval exhibit normal long-term memory for contextual fear
• mice never fed doxycycline or only fed doxycycline during development but not during adulthood only exhibit impaired spatial learning in a Morris water maze compared with wild-type mice
• mice never fed doxycycline or only fed doxycycline during development or during adulthood only exhibit impaired spatial memory in a Morris water maze compared with wild-type mice
• in mice never fed doxycycline or only fed doxycycline during adulthood but not during development only

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
schizophrenia DOID:5419 OMIM:181500
J:166114


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory