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Phenotypes Associated with This Genotype
Genotype
MGI:4840220
Allelic
Composition
Ighatm1(Myc)Janz/Igha+
Tg(Tnfsf13b)1Fma/0
Genetic
Background
involves: 129S1/Sv * C57BL/6 * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighatm1(Myc)Janz mutation (1 available); any Igha mutation (9 available)
Tg(Tnfsf13b)1Fma mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• splenomegaly is obvious in males after 4 months of age

mortality/aging
• median lifespan of mice with leukemia is 10 months

hematopoietic system
• splenomegaly is obvious in males after 4 months of age
• males develop lymphocytosis at 3 months of age
• males exhibit an increase in blood B-cell number, with an expansion of the CD5+CD3-B220low IgMlow B-cell population in blood and spleens
• B-cell increase results from a monoclonal expansion of mature B cell-like cells
• 8 month old spleens of males exhibit enlarged white pulp with loss of normal splenic architecture resulting from a diffuse infiltration of mature lymphocytes

immune system
• splenomegaly is obvious in males after 4 months of age
• males develop lymphocytosis at 3 months of age
• males exhibit an increase in blood B-cell number, with an expansion of the CD5+CD3-B220low IgMlow B-cell population in blood and spleens
• B-cell increase results from a monoclonal expansion of mature B cell-like cells
• 8 month old spleens of males exhibit enlarged white pulp with loss of normal splenic architecture resulting from a diffuse infiltration of mature lymphocytes

neoplasm
• mutants, mainly males, develop a CD5+ B-cell lymphoproliferative disease by 8 months of age that resembles human chronic lymphocytic leukemia
• male mice exhibit increased splenic 18F-labeled 2-fluoro-2-deoxy-D-glucose (FDG) uptake suggesting elevated leukemic cell metabolism


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/17/2022
MGI 6.19
The Jackson Laboratory