Phenotypes Associated with This Genotype

Genotype
MGI:4840220

• Allelic Composition: Igha^tm1(Myc)Janz/Igha⁺; Tg(Tnfsf13b)1Fma/0
• Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:166158 )

• median lifespan of mice with leukemia is 10 months

hematopoietic system

enlarged spleen ( J:166158 )

• splenomegaly is obvious in males after 4 months of age

increased lymphocyte cell number ( J:166158 )

• males develop lymphocytosis at 3 months of age

increased B cell number ( J:166158 )

• males exhibit an increase in blood B-cell number, with an expansion of the CD5+CD3-B220^low IgM^low B-cell population in blood and spleens

increased mature B cell number ( J:166158 )

• B-cell increase results from a monoclonal expansion of mature B cell-like cells

increased spleen white pulp amount ( J:166158 )

• 8 month old spleens of males exhibit enlarged white pulp with loss of normal splenic architecture resulting from a diffuse infiltration of mature lymphocytes

immune system

enlarged spleen ( J:166158 )

• splenomegaly is obvious in males after 4 months of age

increased lymphocyte cell number ( J:166158 )

• males develop lymphocytosis at 3 months of age

increased B cell number ( J:166158 )

• males exhibit an increase in blood B-cell number, with an expansion of the CD5+CD3-B220^low IgM^low B-cell population in blood and spleens

increased mature B cell number ( J:166158 )

• B-cell increase results from a monoclonal expansion of mature B cell-like cells

increased spleen white pulp amount ( J:166158 )

• 8 month old spleens of males exhibit enlarged white pulp with loss of normal splenic architecture resulting from a diffuse infiltration of mature lymphocytes

neoplasm

increased chronic lymphocytic leukemia incidence ( J:166158 )

• mutants, mainly males, develop a CD5+ B-cell lymphoproliferative disease by 8 months of age that resembles human chronic lymphocytic leukemia

• male mice exhibit increased splenic ¹⁸F-labeled 2-fluoro-2-deoxy-D-glucose (FDG) uptake suggesting elevated leukemic cell metabolism

growth/size/body

enlarged spleen ( J:166158 )

• splenomegaly is obvious in males after 4 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic lymphocytic leukemia		DOID:1040	OMIM:109543 OMIM:151400 OMIM:609630 OMIM:612557 OMIM:612558 OMIM:612559	J:166158