Phenotypes Associated with This Genotype

Genotype
MGI:4840002

• Allelic Composition: Lepr^m5Btlr/Lepr^m5Btlr
• Genetic Background: C57BL/6-Lepr^m5Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating insulin level ( J:166105 )

increased circulating leptin level ( J:166105 )

abnormal circadian temperature homeostasis ( J:166105 )

• during the dark phase

decreased carbon dioxide production ( J:166105 )

decreased oxygen consumption ( J:166105 )

decreased respiratory quotient ( J:166105 )

impaired glucose tolerance ( J:166105 )

insulin resistance ( J:166105 )

abnormal response/metabolism to endogenous compounds ( J:166105 )

• mice treated with leptin fail to exhibit a decrease in food intake unlike similarly treated wild-type mice

adipose tissue

increased brown adipose tissue amount ( J:166105 )

increased total body fat amount ( J:166105 )

• mice exhibit increased omental, mesenteric, and subcutaneous adipose weight compared with wild-type mice

increased mesenteric fat pad weight ( J:166105 )

increased omental fat pad weight ( J:166105 )

behavior/neurological

abnormal eating behavior ( J:166105 )

• during the dark

decreased locomotor activity ( J:166105 )

growth/size/body

increased body weight ( J:166105 )

• mice exhibit increased body weight compared with wild-type mice and Lepr^db homozygotes

obese ( J:166105 )

• on normal chow

increased liver weight ( J:166105 )

liver/biliary system

increased liver weight ( J:166105 )