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Phenotypes Associated with This Genotype
Genotype
MGI:4839508
Allelic
Composition
Erbb2tm8(Erbb2)Mul/Erbb2+
Ptentm1Hwu/Pten+
Tg(MMTV-cre)7Mul/0
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2tm8(Erbb2)Mul mutation (0 available); any Erbb2 mutation (21 available)
Ptentm1Hwu mutation (3 available); any Pten mutation (43 available)
Tg(MMTV-cre)7Mul mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• mammary tumor onset is accelerated in virgin females compared with either single Pten or single Erbb2 mutants, with tumor latencies of 6.5 compared with 15.3 months
• tumor progression is associated with loss of heterozygosity at the Pten locus in 50% of mutant mammary tumors
• tumors are similar to basal-like subtype of human breast cancer

endocrine/exocrine glands
• mammary tumor onset is accelerated in virgin females compared with either single Pten or single Erbb2 mutants, with tumor latencies of 6.5 compared with 15.3 months
• tumor progression is associated with loss of heterozygosity at the Pten locus in 50% of mutant mammary tumors
• tumors are similar to basal-like subtype of human breast cancer

neoplasm
• mammary tumor onset is accelerated in virgin females compared with either single Pten or single Erbb2 mutants, with tumor latencies of 6.5 compared with 15.3 months
• tumor progression is associated with loss of heterozygosity at the Pten locus in 50% of mutant mammary tumors
• tumors are similar to basal-like subtype of human breast cancer
• 35% incidence of lung metastases compared with 5% in single Erbb2 mutants

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
OMIM:600048
OMIM:605365
J:133305


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/21/2017
MGI 6.08
The Jackson Laboratory