Mouse Genome Informatics
cn
    Tg(CAG-Has2)99Nita/0
Tg(MMTV-cre)4Mam/0
Tg(MMTVneu)202Mul/0

FVB.Cg-Tg(CAG-Has2)99Nita Tg(MMTV-cre)4Mam Tg(MMTVneu)202Mul
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
tumorigenesis

hematopoietic system
• after macrophage depletion with encapsulated clodronate blood vessels in tumors were mostly small and fragmented
• density of invading macrophage is 7-fold greater in the stroma of tumors compared with Neo in-control

immune system
• after macrophage depletion with encapsulated clodronate blood vessels in tumors were mostly small and fragmented
• density of invading macrophage is 7-fold greater in the stroma of tumors compared with Neo in-control
• mammary gland tumors express more podoplanin+ lymphatic endothelial cells than in Tg(MMTVneu)202Mul Tg(CAG-Has2)99Nita mice
• intratumoral lyphatics are 16-fold greater than in Tg(MMTVneu)202Mul Tg(CAG-Has2)99Nita mice while peritumoral lymphatic vessels are only 1.5-fold greater
• tumor lymphatic vessels are associated with high hyaluronan stroma

cellular
• after macrophage depletion with encapsulated clodronate blood vessels in tumors were mostly small and fragmented

Mouse Models of Human Disease
OMIM IDRef(s)
Breast Cancer 114480 J:164205