Phenotypes Associated with This Genotype

Genotype
MGI:4839392

• Allelic Composition: Tg(CAG-Has2)99Nita/0; Tg(MMTV-cre)4Mam/0; Tg(MMTVneu)202Mul/0
• Genetic Background: FVB.Cg-Tg(CAG-Has2)99Nita Tg(MMTV-cre)4Mam Tg(MMTVneu)202Mul

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:164205 )

increased mammary adenocarcinoma incidence ( J:130531 , J:164205 )

hematopoietic system

impaired macrophage chemotaxis ( J:164205 )

• after macrophage depletion with encapsulated clodronate blood vessels in tumors were mostly small and fragmented

increased macrophage cell number ( J:164205 )

• density of invading macrophage is 7-fold greater in the stroma of tumors compared with Neo in-control

immune system

impaired macrophage chemotaxis ( J:164205 )

• after macrophage depletion with encapsulated clodronate blood vessels in tumors were mostly small and fragmented

increased macrophage cell number ( J:164205 )

• density of invading macrophage is 7-fold greater in the stroma of tumors compared with Neo in-control

abnormal lymphatic vessel morphology ( J:130531 )

• mammary gland tumors express more podoplanin+ lymphatic endothelial cells than in Tg(MMTVneu)202Mul Tg(CAG-Has2)99Nita mice

• intratumoral lyphatics are 16-fold greater than in Tg(MMTVneu)202Mul Tg(CAG-Has2)99Nita mice while peritumoral lymphatic vessels are only 1.5-fold greater

• tumor lymphatic vessels are associated with high hyaluronan stroma

cellular

impaired macrophage chemotaxis ( J:164205 )

• after macrophage depletion with encapsulated clodronate blood vessels in tumors were mostly small and fragmented

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:164205 )

increased mammary adenocarcinoma incidence ( J:130531 , J:164205 )

integument

increased mammary gland tumor incidence ( J:164205 )

increased mammary adenocarcinoma incidence ( J:130531 , J:164205 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:164205