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Phenotypes Associated with This Genotype
Genotype
MGI:4839392
Allelic
Composition
Tg(CAG-Has2)99Nita/0
Tg(MMTV-cre)4Mam/0
Tg(MMTVneu)202Mul/0
Genetic
Background
FVB.Cg-Tg(CAG-Has2)99Nita Tg(MMTV-cre)4Mam Tg(MMTVneu)202Mul
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-Has2)99Nita mutation (0 available)
Tg(MMTV-cre)4Mam mutation (1 available)
Tg(MMTVneu)202Mul mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument

endocrine/exocrine glands

neoplasm

hematopoietic system
• after macrophage depletion with encapsulated clodronate blood vessels in tumors were mostly small and fragmented
• density of invading macrophage is 7-fold greater in the stroma of tumors compared with Neo in-control

immune system
• after macrophage depletion with encapsulated clodronate blood vessels in tumors were mostly small and fragmented
• density of invading macrophage is 7-fold greater in the stroma of tumors compared with Neo in-control
• mammary gland tumors express more podoplanin+ lymphatic endothelial cells than in Tg(MMTVneu)202Mul Tg(CAG-Has2)99Nita mice
• intratumoral lyphatics are 16-fold greater than in Tg(MMTVneu)202Mul Tg(CAG-Has2)99Nita mice while peritumoral lymphatic vessels are only 1.5-fold greater
• tumor lymphatic vessels are associated with high hyaluronan stroma

cellular
• after macrophage depletion with encapsulated clodronate blood vessels in tumors were mostly small and fragmented

Mouse Models of Human Disease
OMIM ID Ref(s)
Breast Cancer 114480 J:164205


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory