Phenotypes Associated with This Genotype

Genotype
MGI:4839089

• Allelic Composition: Fbn1^tm1.2Lysa/Fbn1⁺
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Fragmentation of aortic root elastic lamellae in Fbn1^tm1.2Lysa/Fbn1⁺ mice

cardiovascular system

abnormal aorta elastic fiber morphology ( J:165897 )

• at 2 months, mice exhibit progressive fragmentation of the aortic elastic lamellae with age unlike wild-type mice

muscle

abnormal skeletal muscle fiber morphology ( J:165897 )

• at P8, mice exhibit fragmentation of the microfibril network unlike in wild-type mice

• however, early postnatal assembly of microfibril networks is normal

abnormal tendon morphology ( J:165897 )

• at P8, mice exhibit fragmentation of the microfibril network unlike in wild-type mice

• however, early postnatal assembly of microfibril networks is normal

skeleton

abnormal tendon morphology ( J:165897 )

• at P8, mice exhibit fragmentation of the microfibril network unlike in wild-type mice

• however, early postnatal assembly of microfibril networks is normal

integument

abnormal cutaneous microfibril morphology ( J:165897 )

• at P8, mice exhibit fragmentation of the microfibril network unlike in wild-type mice

• however, early postnatal assembly of microfibril networks is normal